MONDAY, Feb. 9, 2009 (Health.com) — The cold, dry air of winter can give you chapped lips, cracked hands, and now, a study suggests, a better chance of getting the flu. A new analysis of previous data shows that in low-humidity conditions, the influenza virus is more likely survive, possibly giving it a better shot at spreading from person to person and making its way to you.

The finding also suggests that using a humidifier may be a good idea in places where the spread of influenza poses a serious threat, like intensive care units or even a home with a sick child—as long as sensitivity to moisture-loving mold and spores isn’t a problem, according to Jeffrey Shaman, PhD, of Oregon State University in Corvallis, a coauthor of the new study.

“It seems that [the influenza virus’s] ability to survive and be transmitted person-to-person is greatly affected by how dry or wet the air is,” says Shaman, whose study is published in this week’s Proceedings of the National Academy of Sciences.

The name for this potentially deadly respiratory infection comes from the Italian word for influence; centuries ago, people believed that the influence of the planets made people sick with the disease. Our science is a little more solid today, but researchers still aren’t 100% sure how and why the virus spreads, and they remain stumped about why some parts of the world have such a pronounced winter flu season with almost no flu activity in warmer months.

Shaman believes he’s found the answer: It’s all about humidity. Absolute humidity, that is, which is particularly low in cold weather.

Shaman and his colleague Melvin Kohn of the Oregon Department of Health Services in Portland revisited a 2007 study that found higher humidity slowed the spread of the flu among guinea pigs. The researchers had measured air dampness using relative humidity, or how saturated the air is with water vapor.

For example, 75% relative humidity would mean the air is holding 75% of its total capacity of water vapor. Relative humidity is strongly influenced by temperature; the warmer the air, the more water vapor it can hold, while colder air can’t hold as much water vapor.

Absolute humidity, on the other hand, refers to the actual amount of water vapor in the air regardless of saturation. Relative humidity is like a car’s gas gauge, Shaman notes. It tells you how full your tank is. Absolute humidity represents how many gallons you have in your tank, regardless of the tank’s size.

Shaman converted the guinea pig data from relative humidity to absolute humidity and found the link between air moisture and flu spread got much stronger. “Absolute humidity, for reasons that remain undetermined, is affecting how long the virus remains viable,” he says. “It really explains why you have this pronounced seasonality in temperate regions.”

The researcher also looked at studies dating back to the 1940s of airborne flu virus survival. Some included information on relative humidity, which he converted to absolute humidity. Again, the relationship between survival and air moisture got stronger.

For example, in the wettest possible absolute humidity, less than 20% of the virus was still viable after an hour, while at the driest conditions 80% of the virus was still capable of making someone sick. After 23 hours, the viruses in the dampest conditions were all dead, while 60% of those under the most arid conditions were still alive.

“The idea that humidity affects the life of virus has been known for decades,” says Michael Gardam, MD, PhD, an infectious disease specialist with the University Health Network in Toronto and Ontario’s public health agency. While Shaman’s findings are “important,” according to Dr. Gardam, the challenge will now be to see if air humidity affects the spread of the disease among humans in the real world. “Based on the papers that have been done thus far, I wouldn’t run out and buy humidifiers, but I would definitely buy humidifiers to study humidifiers.”

“This is sort of nibbling around the edges,” he added. “It’s useful, but it’s not sufficient to say, ‘We now have the answer to change the world.’”

It’s “frustrating,” Dr. Gardam says, that we still don’t know if the virus is spread mainly by physical contact or through the air or both. For this reason, he adds, there remains no scientific evidence that widely promoted protective measures such as hand washing and mask wearing will actually stop people from getting sick. “We’ve just sort of taken for granted we know how it transmits, and we really don’t know,” he says.

“I think they’ve done a good job. I agree with their work,” says Anice Lowen, PhD, a researcher at the Mt. Sinai School of Medicine in New York and one of the authors of the guinea pig study. “I’m not an expert in the methods that they used, but it seems to make sense.”

The reasons why the flu virus might survive and spread more easily in dry conditions—and why absolute humidity might be a better gauge of these conditions than relative humidity—are still not clear, Lowen notes. It could have something to do with moisture evaporating from surfaces more speedily when humidity is low, she says.

Lowen agrees that keeping indoor air more humid might help slow down the spread of the flu. But, she adds, “the best way to protect yourself against influenza is to get vaccinated.”

Pseudoephedrine

(SOO-doh-eff-ed-rin)

What is it? Commonly found in nonprescription cold and allergy medications like Sudafed and Advil Cold & Sinus, pseudoephedrine eases stuffy noses by shrinking swollen blood vessels in your nasal passages, says John Sundy, MD, an asthma and allergy specialist at Duke University Medical Center.

The buzz: Meds with pseudoephedrine were moved behind the pharmacy counter in 2006, and limits were imposed on how much you can buy. Why? The stuff can be used to make methamphetamine, an illegal drug.

You need to know: If you buy a cold or allergy medication and don’t get your usual relief, it may be because the product contains phenylephrine (available over the counter), not pseudoephedrine, Dr. Sundy says. New research shows that some people with stuffy noses get more relief from pseudoephedrine than phenylephrine.

The bottom line: Read labels so you know your phenyl from your pseudo, and ask your pharmacist for a pseudoephedrine product if you think you need it. Know that the drug slightly raises your risk for high blood pressure and might make you jumpy, Dr. Sundy says.

This article was first published in Health magazine, October 2009.