Premenstrual dysphoric disorder (PMDD): a severe form of the premenstrual syndrome (PMS). Both premenstrual syndrome and premenstrual dysphoric disorder are characterized by unpleasant physical and psychological symptoms (such as fatigue, mood changes, irritability, and abdominal bloating) that occur in the second half of a woman’s menstrual cycle, most commonly in the days preceding the menstrual period. PMDD is more severe than PMS and can cause severe, debilitating symptoms that interfere with a woman’s ability to function. While PMS may affect to 30 percent of women with regular menstrual cycles, only 3-8% of these women have true PMDD. The exact cause of PMDD is unknown, but it is believed to be related to the interaction of ovarian hormones (estrogen and progesterone) with the neurotransmitters (chemicals that serve as messengers) in the brain. PMDD has been previously referred to as late luteal phase dysphoric disorder.

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